• October 2020 : 5 presentations by LITO at the European Association of Nuclear Medicine meeting this year, on-line, from the 22nd to the 30th of October. Our presentations report our results and views on radiomics, dynamic PET and promises of total body PET, and detection performance of the Vereos scanner. 

  • October 2020 : We are happy to welcome Nicolas Captier, as a new PhD student in the lab. Nicolas will actually prepare his PhD through a joint venture between U900 Inserm-Institut Curie (Emmanuel Barillot unit) and LITO and will work on the TIPIT project, to analyze and integrate various data types (omics, radiomics, pathology, clinical data) to understand resistance to immunotherapy in lung cancer patients.
  • October 2020 : Anne-Sophie Dirand has just successfully defended her PhD thesis that she has been preparing with us for 3 years, and that is entitled "Methodological developments for the use of radiomic features". Anne-Sophie is now finalizing her training in Saclay to become a medical physicist. To know more about her experience, do not hesitate to look at her informal interview !

  • September 2020 : Fanny Orlhac et al paper validating ComBat in the context of MRI multicenter studies and published in European Radiology is now accessible on line : https://pubmed.ncbi.nlm.nih.gov/32975661/. Let us hope it will become as popular as the similar papers we published in PET and in CT (see news of August 2020).
  • Septembre 2020 : the virtual ESMRMB starts September 30th.  Marie-Judith Saint-Martin and Maxime Lacroix will present lightning talks and e-posters during the meeting.  

  • Septembre 2020 : LIFEx now has more than 3500 users. After a large spread in Europe and Asia, the software is now used in North America by almost 500 users. 

  • September 2020 : We are very happy to have organized, together with our German and Austrian colleagues, the 1st virtual summer school on Radiomics and AI in Nuclear Medicine.  Warm thanks to all participants from all over the world that made these 3 days a great success, thanks to their active participation and their involvement in the discussions and hands-on. 
  • August 2020 : The AI.DReAM project (2020-2025), standing for "Artificial Intelligence for Diagnostic, Review and radiomics Acceleration in Medicine", led by General Electric, Healthcare and for which July 2020 : Seven presentations involving radiomics, AI or digital PET/CT are given by LITO members during the Virtual Edition of the Society of Nuclear Medicine and Molecular Imaging meeting taking place on the 11-14th July. Great exposure of our research work as more than 8,000 attendees have registered to that unique virtual event!
  • July 2020 : The PRECISION PREDICT project, led by Institut Curie (Thoracic Oncology Department, Data Department, and LITO), is one of the 10 projects that will be funded, among 138 applications, as part of the Health Data Hub call related to the "Improvement of medical diagnosis through the use of Artificial Intelligence".  Together with 8 other Cancer Centers in France, the goal is to create a large database of clinical and radiological imaging (PET/CT and CT scans) data in patients with lung cancer associated with an EGFR mutation and treated with targeted therapy. Using this database, our aim is to better understand the observed variety of response to the treatment among patients, and to try predict, for each individual patient, whether he will benefit or not from the treatment and for how long. 
  • July 2020 : The TIPIT project, that gathers U900 Inserm - Institut Curie - PSL (Head : Emmanuel Barillot), the Thoracic Oncology Department (Head : Nicolas Girard), and LITO, has just been funded for 3 years by Fondation ARC, as part of the SIGNIT call for projects. This project aims at integrating a broad variety of data reflecting different aspects of non small cell lung tumors measured at various scales (molecular, cellular, tissue) so as to obtain a comprehensive view of the tumor profile and of its microenvironment. We will then try to use these profiles to predict the response to immunotherapy with an accuracy that would be sufficient to be clinically useful.  

  • June 2020 : Fanny Orlhac receives the Tracy Lynn Faber Memorial Award, which is given each year by The Physics, Instrumentation and Data Sciences Council (PIDSC) of the American Society of Nuclear Medicine and Molecular Imaging to support advancement of women in medical imaging sciences. Fanny is honored for outstanding contributions to Radiomics in PET imaging, including advances in methodological rigor and strengthened biological and clinical relevance.
  • June 2020 : Opening of Avicenne Hospital as a participant to the "Validation and Optimization methods for a quantitative Characterization of motion Abnormalities of the Larynx with Echography" clinical trial (PI C Trésallet, Avicenne, APHP, Scientific in charge: F Frouin, Collaborator Mindray, https://clinicaltrials.gov/ct2/show/NCT03976011). The goal of this trial is to validate Transcutaneous Laryngeal Ultrasonography (TLU) as a good alternative to nasofibroscopy in evaluating vocal fold mobility after endocrine surgery. It is a prospective multicentric study that will blindly compare TLU and nasofibroscopy, the latter being the gold standard.

  • June 2020 : A convolutional neural network enables the automated estimation of the metabolically active tumor volume from FDG PET images and the predictive value of these volumes in terms of progression free survival and overall survival is similar to the volumes estimated by expert Nuclear Medicine physicians. Read these original new results in our latest paper published in Journal of Nuclear Medicine in collaboration with Siemens and several French hospitals.
  • May 2020 : Our LIFEx software now has more than 3000 users. A great thank you to all LIFEx users for their feedback that helps us improve the software !

  • May 2020 : The article published as part of the Image Biomarker Standardization Initiative (IBSI) to describe how radiomic features should be calculated is just out in Radiology. LIFEx provides features that are fully IBSI-compliant as demonstrated in that paper.
  • April 2020 : The PANACEE project (PANomic Atlas for non-small CEll lung cancer managEment) led by Fanny Orlhac and submitted to the Janssen Horizon call regarding the role of Artificial Intelligence in neurology, psychiatry, oncology, infectious diseases and auto-immune disease has been favorably assessed by the Scientific Committee and the Administration Council of Janssen Horizon and will be funded by Janssen Horizon foundation for 3 years. The ultimate goal of that project is to improve the management of patients with lung cancer by integrating multi-omic information.
  • March 2020 : Lockdown in LITO. We have set up a LITO virtual lab using Discord so that LITO lab life can go on based on virtual meetings and virtual exchanges between colleagues. 
  • March 2020 : How to estimate the arterial input fonction that is needed for accurate quantification in rodent PET ? Our solution and associated validation are just in print in the European Journal of Nuclear Medicine and Molecular Imaging

  • March 2020 : We are happy to have participated to the international IBSI initiative regarding the definition of radiomic features and the validation of their implementation through the distribution of test data. This work also allowed us to demonstrate that our LIFEx software complies with the IBSI standard. Please look at the corresponding publication in Radiology, which should facilitate reproducible radiomics. 

  • February 2020 : It is a great honor for LITO to have the opportunity to contribute to the Inserm transverse programme AGEMED that has just been renewed as AGEMED 2.0, under the leadership of Eric Gilson. LITO's role will be to investigate the potential of PET for detecting and characterizing molecular signals associated with cell and tissue aging. 
  • January 2020 : The work by Maxime Lacroix et al, regarding MR radiomics in lung cancer patients, has just been accepted for publication in Frontiers in Oncology. In this paper, we demonstrate the need for compensating for magnetic field heterogeneities and for normalizing voxel values in MR images to increase the sensitivity of radiomic features.

  • January 2020 : Our paper demonstrating for the first time the prognostic value of a radiomic biomarker characterizing tumor dissemination in patients with diffuse large B-cell lymphoma has just been published in the Journal of Nuclear Medicine !

  • December 2019 : Our HOLY2020 project is one of the 6 projects that have been funded as part of the H2020 EraCoSysMed call. This is a 3-year project (2020-2023) dedicated to the development of artificial intelligence models for precision medicine in patients with early Hodgkin Lymphoma using FDG PET. Methodological developments will be performed by LITO in collaboration with the University of Vienna (Prof Alexander Haug) and San Pau hospital in Barcelona (Prof Ignasi Carrio).

  • December 2019 : Our LIFEx software now has more than 2500 users. A great thank you to all LIFEx users for their feedback that helps us improve the software !