The TIPIT project (2020-2023), who involves U900 Inserm - Institut Curie - PSL (Head : Emmanuel Barillot), the Department of thoracic oncology of Institut Curie (Head : Nicolas Girard) and our lab is funded by the ARC fondation, as part of the SIGNIT call, for 3 years.
The project will consist in gathering a database of genomic, radiomic, clinical and pathological data in 200 patients with non small cell lung cancer to get a comprehensive view of each tumor and of its microenvironment. By mining these data, we will characterize each tumor using a multiscale approach, and will try to predict their response to immunotherapy using artificial intelligence methods. The goal is to get a prediction that would be accurate enough to be clinically useful for patient management.
People involved in the lab : Hervé Brisse, Toulsie Ramtohul, Marie Luporsi, Nicolas Captier, Fanny Orlhac (co-responsible for the lab), Irène Buvat (co-responsible for the lab).
Publications :
- Captier N, Orlhac F, Hovhannisyan-Baghdasarian N, Luporsi M, Girard N, Buvat I. RadShap: an explanation tool for highlighting the contributions of multiple regions of interest to the prediction of radiomic models. J Nucl Med, 65:1307-1312, 2024. DOI: https://doi.org/10.2967/jnumed.124.267434
- Hovhannisyan-Baghdasarian N, Luporsi M, Captier N, Nioche C, Cuplov V, Woff E, Hegarat N, Livartowski A, Girard N, Buvat I, Orlhac F. New promising candidate prognostic biomarkers in [18F]FDG-PET images: evaluation in independent cohorts of NSCLC patients. J Nucl Med, 65:635-642, 2024. DOI: 10.2967/jnumed.123.266331