Photo Dynamic Therapy (PDT) is a localized treatment using a laser beam focused on the tumor. The PDT is based on the activation by specific wavelength light of a photosensitizer (PS) localized preferentially in tumor cells. This generates oxygenated species toxic to the cells internalizing PS. PS is non mutagenic and pharmacologically inactive without lighting. We have shown that PDT is effective on retinoblastomas developing in the eyes of transgenic mice. Our project aims at evaluating PDT on a model developing tumours in the vitreous or retina in rats. This PDT approach will be compared to a more conventional radiotherapy treatment. We will also evaluate this treatment with uveal melanoma and compare its efficiency with that of radiotherapy which is a gold standard for this pathology.